Pierre MICHETTI

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Pubmed Publications List

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Professor of Gastroenterology and Hepatology
Division de Gastro-entérologie et d’Hépatologie
Centre Hospitalier Universitaire Vaudois
Rue du Bugnon 46
CH-1011 CHUV-Lausanne, Switzerland

phone +41 21 314 0690

fax +41 21 314 0707

E-mail pierre.michetti@chuv.hospvd.ch

 

Education

• 1977 Bachelor in Sciences, Lausanne, Switzerland

• 1983 Swiss diploma of Physicians, Faculty of Medicine Lausanne University, Lausanne, Switzerland

• 1988 MD Thesis, Faculty of Medicine Lausanne University, Lausanne, Switzerland

• Speciality in Internal Medicine and Gastroenterology

 

Professional Experience

• 1984-1986 Resident Surgery and Internal Medicine, Samaritain Hospital Vevey, Switzerland

• 1986-1988 Research Fellow, Biochemistry Institute, Lausanne University, Switzerland

• 1988-1990 Assistant Lecturer, Biochemistry Institute, Lausanne University, Switzerland

• 1990-1991 Post-doctoral Research Fellow, Children’s Hospital and Harvard Medical School, Boston, USA

• 1991-1994 Fellow in Gastroenterology, University Hospital, Lausanne, Switzerland

• 1994-1996 Senior Fellow in Gastroenterology, University Hospital, Lausanne, Switzerland

• 1996-2000 Co-Director, Center for Inflammatory Bowel Disease, staff physician, Beth Israel Deaconess Medical Center, Assistant Professor in Medicine, Harvard Medical School Boston, MA

 

Selected Honours, Awards & Editorial Posts

• 1992 Swiss Society for Gastroenterology & Hepatology Research Development Award

• 1994 Swiss Society for Gastroenterology & Hepatology Honor Award

• 1997 Glaxo-Wellcome Institute for Digestive Health Award

• Since 1992 Swiss Representative of the European Helicobacter Pylori Study Group

• Since 1994 Co-editor of The Year in H. pylori on behalf of the EHPSG

• Since 1996 Editorial board Helicobacter

 

Research Interests

• Mucosal immunology and Vaccine Development

• Immune response to H. pylori infection and immunisation

 

Selected Original Articles

• Weltzin RA, Lucia Jandris P, Michetti P, Fields BN, Kraehenbuhl JP, Neutra MR. Binding and transepithelial transport of immunoglobulins by intestinal M cells: demonstration using monoclonal IgA antibodies against enteric viral proteins. J Cell Biol 1989;108:1673-1685.

• Amerongen HM, Weltzin RA, Farnet CM, Michetti P, Haseltine WA, Neutra MR. Transepithelial transport of HIV-1 by intestinal M cells : a mechanism for transmission of AIDS. J Acquir Immune Defic Syndr 1991;4:760-765.

• Michetti P, Mahan MJ, Slauch JM, Mekalanos JJ, Neutra MR. Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium. Infect Immun 1992;60:1786-1792.

• Hirt R, Hughes GJ, Frutiger S, Michetti P, Perregaux C, Poulain-Godefroy O, Janguenat N, Neutra MR, Kraehenbuhl JP. Trancytosis of the polymeric Ig receptor is requires phosphorylation on Serine 664 in the absence but not the presence of dimeric IgA. Cell 1993;74:245-255.

• Apter FM, Michetti P, Winner LS, Mack JA, Mekalanos JJ, Neutra MR. Analysis of the roles of antilipo-polysaccharide and anti-cholera toxin immunoglobulin A (IgA) antibodies in protection against V. cholerae and cholera toxin by use of monoclonal IgA antibodies in vivo. Infect Immun 1993;61:5279-5285.

• Michetti P, Porta N, Mahan MJ, Slauch JM, Mekalanos JJ, Blum AL, Kraehenbuhl JP, Neutra MR. Monoclonal IgA prevents adherence and invasion of polarized epithelial cell monolayers by Salmonella typhimurium. Gastroenterology 1994;107: 915-923. Related editorial pp.1193-1195.

• Michetti P, Corthésy-Theulaz I, Davin C, Haas R, Vaney AC, Heitz M, Bille J, Kraehenbuhl JP, Saraga E, Blum AL. Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease. Gastroenterology 1994;107: 1002-1011.

• Slauch JM, Mahan MJ, Michetti P, Neutra MR, Mekalanos JJ. Acetylation (O-factor 5) affects the structural and immunological properties of lipopolysaccharide O antigen. Infect Immun 1995;63:437-441.

• Corthésy-Theulaz I, Porta N, Glauser M, Saraga E, Vaney AC, Haas R, , Kraehenbuhl JP, Blum AL, Michetti P. Oral immunization with Helicobacter pylori urease B as a treatment against Helicobacter infection. Gastroenterology 1995;109:115-121.

• Glauser MH, Michetti P, Blum AL, Corthésy-Theulaz I. Carbon 14-urea breath test as a non-invasive method to follow H. felis colonisation in mice. Digestion 1996;57:30-34.

• Verdù EF, Fraser R, Tiberio D. Herranz M, Sipponen P, Blum AL, and Michetti P. Prevalence of Helicobacter pylori infection and chronic dyspeptic symptoms among immigrants from developing countries and people born in industrialised countries. Digestion. 1996;57:180-185.

• Kreiss C, Buclin T, Cosma M, Corthésy-Theulaz I, Michetti P. Safety of oral immunisation with recombinant urease against Helicobacter pylori infection. Lancet 1996;347:1630-1631.

• Corthésy-Theulaz I, Porta N, Pringault E, Racine L, Bogdanova A, Kraehenbuhl JP, Blum AL, and Michetti P. Adhesion of Helicobacter pylori to T84 human intestinal cell monolayers is pH-dependent. Infect Immun 1996;64:3827-2832.

• Michetti P, Kreiss C, Kotloff KL, Porta N, Blanco JL, Bachmann D, Herranz M, Saldinger PF Corthésy-Theulaz I, Losonsky G, Nichols R, Simon J, Stolte M, Ackerman S, Monath TP, Blum AL. Oral immunization with recombinant urease and E. coli heatlabile enterotoxin adjuvant is safe and immunogenic in H. pylori infected adults. Gastroenterology 1999;116:804-812.

• Michetti P, G. Dorta G, Wiesel PH, Brassart D, E. Verdu H, Herranz M, Felley C, Porta N, Rouvet M, Blum AL, Corthésy-Theulaz I. The effect of whey-based culture supernatant of Lactobacillus acidophilus la 1 on Helicobacter pylori infection in humans. Digestion 1999; 60: 203-209.

• Michetti M, Kelly CP, Kraehenbuhl JP, Bouzourene H, Michetti P. Gastric mucosal a4b7 integrin-positive lymphocytes and immune protection against helicobacter infection in mice. Gastroenterology 2000; 119: 109-118.

• Felley CP, Corthésy-Theulaz I, Blanco Rivero JL, Sipponen P, Kaufmann D, Bauerfeind P, Brassart D, Pfeifer A, Blum AL, Michetti P. Favorable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man. In press

•  Selected Review Articles

• Michetti P, Wadström T, Kraehenbuhl JP, Lee A, Kreiss C, Blum AL. Frontiers in Helicobacter pylori research: pathoegenesis, host response, vaccine development and new therapeutical approaches. Eur J Gastroenterol 1996;8:717-722.

• Saldinger P, Michetti P. Changes in Immunologic Effector Responses after immunization for H. pylori. In Ernst PB, Michetti P, and Smith PD, eds. Immunobiology of H. pylori, from pathogenesis to Prevention. Lippincott-Raven, Philadelphia-New York, USA 1997;287-296.